is there any script api to modify dll file

there is a dll, compiled from some fixed code, the compiler is miniGW 64bit installed in windows.And in the dll there is some static variables in one specific function. Now, I want to modify the static variable's initial value automatically, and then save the a new dll. the initial value is get from other scripts. Not to load the dll, but to modify the dll quietly by script, python or other scripts, or c/c++. As I know there is symbol table in the dll, there must be some methods to visit or modify the variable.